Brainbox Initiative Webinar: TMS Electro-diagnostic Markers as a Clinical Readout for Testing Novel CNS Therapeutics
Dr Isabella Premoli of Kings College London joins us on August 26 for this one-hour webinar TMS Electro-diagnostic Markers as a Clinical Readout for Testing Novel CNS Therapeutics, run in collaboration with specialist neuroscience contract research services provider The Science Behind.
Transcranial Magnetic Stimulation (TMS) is a non-invasive brain stimulation technique which in combination with electromyography (EMG) and electroencephalography (EEG) offers an array of electro-diagnostic markers (EDM) able to assess human brain excitability and functionality in health and disease. The observation of TMS responses before and after the administration of drugs with well-known and specific mechanisms of action contributed to the development of markers of cortical and cortico-spinal inhibitory and excitatory processes. Hence, TMS started to be used in early-stage and first-in-human clinical trials of new therapeutics to obtain pharmacodynamic EDM for biological target engagement.
Isabella will show recent use of TMS-EDM to evaluate (i) in-vivo markers for pharmacological activity; (ii) in-vivo markers for specific biological processes (i.e., GABAergic inhibition, voltage-gated channel ligand activity).
This webinar will take place at 14:00 BST on August 26, and will last for approximately one hour with time for questions.